We supply Milbemycin oxime API

We offer Milbemycin oxime API, a potent anthelmintic drug used to treat a wide range of parasitic infections in animals. it is highly effective against heartworms, hookworms, and other intestinal parasites. Our product is high quality and purity, and is manufactured under strict GMP guidelines. We can provide Milbemycin oxime in bulk quantities to meet your needs. Contact us today to learn more about our Milbemycin oxime and how it can benefit your animal health products.

What is Milbemycin oxime API?

Milbemycin oxime is a important and effective antiparasitic medicine that's generally used to treat a variety of internal and external spongers in faves similar as tykes and pussycats. It belongs to the macrocyclic lactone class of medicines and workshop by paralyzing and killing the spongers that calculate on the affected organisms for their survival.

This largely active component is generally administered via oral tablets or chewable tablets with food and water, making it easy and accessible for pet possessors to give their faves with the colorful health benefits of this drug. It has a strong and harmonious efficacity against colorful roundworms, hookworms, whipworms, and heartworms, as well as certain types of diminutives and ticks.

It is an FDA- approved component and is extensively honored as safe and effective for use in pet healthcare. The API is also extensively used in veterinary pharmacology for its broad- diapason antiparasitic parcels and is incorporated into a number of ingrained products that are available in colorful strengths and tablets.

Overall, it is an important and largely effective tool in the veterinarian's magazine against parasitic infections. It provides a safe and dependable means of precluding and treating colorful types of parasitic infections in faves , making it an essential component in the care and treatment of companion creatures.

Basic Information

Product Name: Milbemycin oxime

CAS: 129496-10-2

MF:2C32H45NO7.2C31H43NO7

MW:2194.78

EINECS:206-141-6

MDL No.:MFCD09038910

Structural formula:

Purity: 99%+

Origin: China

Application: antiparasitic drug

Delivery Time: stock

Melting point: 169.6-177.4 ℃

Flash point: 412 ℃

Stability: hygroscopicity

Technical Specification:

Package: 1kg; 25kg

Storage conditions: keep tightly closed, store in a cool dry place.

What is the application of Milbemycin oxime API?

Milbemycin oxime API is currently a highly effective drug for preventing and treating internal and external parasites in dogs and cats. It can effectively prevent and treat heartworms, as well as internal parasites such as hookworms, roundworms, whipworms, roundworms, and roundworms, as well as external parasites such as hair follicle worms, scabies, lice, and fleas. it can paralyze parasites and cause death. It does not have adverse effects on nerve conduction in mammalian animals, and even has no effect on Shepherds with high blood-brain barrier permeability.

In 1997, Taiwan launched Beimai Xin, mainly composed of Milbeoxime, produced by Novartis Taiwan Co., Ltd., as a Chemicalbook drug for preventing heart worms and intestinal parasites in dogs and cats. This was the first time it was used in China. It has a broad-spectrum antiparasitic effect and has a good repellent effect on both in vivo and in vitro parasites, especially nematodes and arthropods.

Chemical property

It is an oxime derivative of Milbemycin D. Milbemycin D contains hydroxyl groups at the carbon-5 and carbon-7 positions, separate double bonds at the carbon-3 and carbon-14 positions, and conjugated diene structures are formed by carbon-8 and carbon-11. The Sankyo group undergoes chemical transformation of the allyl hydroxyl group at position 5, and a series of oxime derivatives are synthesized from Milberomycin A4 and A3. The carbon-5 hydroxyl group is quantitatively oxidized into ketones by manganese dioxide in Chemicalbook. This kind of ketone containing α，β- Hydroxylamine hydrochloride reacts with dioxane methanol water to produce a series of 5-oxime milberberine. it mainly contains Milbemycin A3 oxime and A4 oxime, with Milbemycin A4 oxime not less than 80% and A3 oxime not exceeding 20%. It is a yellow crystalline powder with an unpleasant odor, easily soluble in organic solvents such as benzene, acetone, ethanol, methanol, and chloroform, but insoluble in water.

What is the side effect of Milbemycin oxime API?

Although the side effects of Milbemycin oxime are extremely rare, due to different animal conditions, infection status, and dosage, some may experience toxic symptoms such as extreme depression, anorexia, drowsiness, vomiting, diarrhea, epilepsy, and physical weakness in pets after medication, as well as facial swelling, urticaria, acute diarrhea, shock, etc. Therefore, medication should also be taken under the guidance of a veterinarian.

What is the Production methods of Milbemycin oxime API?

(1) Oxidation reaction: Using milberberine as the raw material, hypochlorite or chlorite as the oxidant, piperidine nitrogen oxide radicals as the catalyst, halides as co catalysts, react in dichloromethane solvent at -5-15 ℃ for 0.5-4h, and the chemical product is post-treated to obtain the intermediate product milberberine;

(2) Oxime reaction: Methanol and 1,4-dioxane are used as reaction solvents, hydroxylamine hydrochloride is used as oxime reagent, and the reaction is carried out at 25-35 ℃ for 10-16 hours. After post-treatment and purification, Milbeoxime is obtained.

In conclusion

In summary, as a professional Milbemycin oxime API manufacturer, we have advanced technology, scale advantage, the best quality, rich production experience, and excellent services. These advantages will make it stand out in the market competition and win more customer trust and support. if you need Milbemycin oxime powder, pls feel free to contact us any time. we will reply you asap.

our contact information:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
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