We supply Verteporfin API

We supply high- quality Verteporfin API to meet your medicinal conditions. it also known as Visudyne, is a drug used in the treatment of macular degeneration and other affiliated eye conditions. Our API is manufactured using the most advanced processing technology and meets transnational norms for quality and chastity. We're committed to icing that our products give the loftiest position of efficacity and safety to cases. Our educated platoon of professionals is devoted to furnishing excellent client service and specialized support. communicate us moment to learn further about our Verteporfin and how we can meet your medicinal needs.

What's Verteporfin?

Verteporfin is also known as 9- methyl( I) and 13- methyl( II) trans-( ±) a- dihydro -3,4-bis( methyl)- 4 a,- tetramethyl- 23H, 25H- phenylporphyrin -9,13-dipropyl ester. This product is a dark green loose block. it treatment is suitable for cases with secondary age- related macular degeneration, pathological presbyopia, or suspected optic histiocytosis, mainly characterized by typical choroidal neovascularization in the fovea. There is shy validation to support its treatment in cases with generally robe choroidal neovascularization in the fovea. it is a alternate- generation porphyrin photosensitizer that can be actuated by light( wavelength 689nm) and can be used for photodynamic remedy to treat macular degeneration. drugs can extensively enter abnormal blood vessels, induce reactive oxygen species through non thermal shaft irradiation, and block abnormal blood vessels, thereby terminating vascular leakage and conserving vision. After being actuated by light, it forms cytotoxic products in an aerobic terrain. During this process, porphyrins transfer the absorbed energy to oxygen, forming largely active and short- lived monooxygens. Monooxygen destroys various natural structures within its diffusion range. This process leads to original vascular occlusion, cell damage, and cell death in specific surroundings. In tube, it is mainly transported by low- density lipoprotein( LDL). its use for photodynamic remedy( PDT) is picky. On the one hand, it depends on the selection of the point of light irradiation, and on the other hand, it depends on the increased expression of LDL receptors in swiftly proliferating cells, including choroidal neovascular endothelial cells, so that swiftly proliferating cells can extensively and snappily uptake and accumulate it. Choroidal neovascularization has a hastily and further picky uptake than retinal color epithelium, while the drug content is fairly low in other optic structures. therefore, picky destruction of choroidal neovascularization is possible. Used for conditions analogous as wet age- related macular degeneration, pathological presbyopia, and choroidal neovascularization in the fovea of the macula, which can beget continuous deterioration or loss of vision.

Basic Information

Product Name: Verteporfin(DB00460)

CAS: 129497-78-5

MF:2C41H42N4O8

MW:1437.61

MDL No.:MFCD11982858

Structural formula:

Origin: China

Application: Lab research

Delivery Time: in stock

Technical Specification

Package: 1g;10g; or according to your demands

Storage conditions: 2-8 ℃, dark, moisture-proof, sealed and dry

Transportation conditions: Transportation at room temperature

Shelf Life: 24 months

Usage:

Research reagent, widely used in molecular biology, pharmacology and other scientific exploration fields, rigorously banned for use in the mortal body. it is a photosensitizer used in photodynamic remedy to exclude abnormal intraocular blood vessels associated with age- related macular degeneration and other conditions. it is a gob asset that can disrupt YAP- TEAD relations.

Biological activity

Verteporfin API ( CL318952, Visudyne) is a small patch emulsion that can inhibit YAP TEAD commerce and inhibit gob convinced liver overgrowth. Meanwhile, it's also an effective alternate- generation photosensitizer deduced from porphyrins. it is an autophagy asset. it can inhibit cell proliferation and induce apoptosis.

In vitro research

For the immersion of light at the stylish wavelength( i.e., roughly 700nm) that penetrates apkins, it is roughly 4 times further effective than hematophorin, furnishing advanced cytotoxicity than hematophorin( further than 10 times in mortal disciple cells). it is lipophilic and is more fluently taken up by nasty or actuated cells compared to normal or sleeping cells. it binds to LDL to form a complex, which may also be taken up by proliferating cells( similar as neovascular endothelial cells) through LDL receptors or endocytosis. it remedy achieves complete occlusion of the neovascularization area through the conformation of thrombi in vascular channels, leading to picky endothelial injury. it remedy widely induces renewable and ex vivo choroidal capillary occlusion without altering the covered photoreceptors or ganglion cells, as shown by optic and electron microscopy. The activation of caspase- 3 and caspase- 9 in HL- 60 cells, as well as the fractionalization of PARP, reflect that under the presence of light, it fleetly induces changes in cell apoptosis, which are blocked by the common caspase assetZVAD.fmk.

In vivo research

Verteporfin can be used for vascular visualization of choroidal vessels and CNVs, indicating rapid-fire aggregation of photosensitizers in experimental CNVs in monkeys. it fleetly accumulates in the choroidal vascular system, RPE, and photoreceptors of the established rabbit eyes. In mice, after intravenous injection for 3 hours, it reached its maximum towel position and also fleetly dropped within 24 hours. it is metabolized into a less active form in the body and snappily cleared, substantially through fecal excretion, with a small portion excreted through urine. it remedy effectively widely averted the leakage of fluorescent colorings from experimentally convinced monkey CNVs.

Liquid storage configuration

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Rich experience: we have 13 Years of professional experience;

Customers all over the world: sell to more than 100 countries;

Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.

Price advance: low MOQ with competitive price;

Quality certification: ISO; Halal; Kosher certified

After-sales service: Professional team 7*24 hours customer service.

Contact Us:

Yihui takes pride in being a trusted Verteporfin API manufacturer and supplier. To acquire this groundbreaking product or discuss your specific requirements, contact us immediately at sales@yihuipharm.com. Rest assured, with Yihui, you're accessing a product of unparalleled quality, backed by certifications that underscore our commitment to excellence in the global market.