Methylcobalamin powder
Appearance: Dark red crystal or crystalline powder
Standard: USP
Supply Ability:1000kg per month
Shelf Life: Two years
Payment: T/T, LC or DA
Delivery Time: Ready Stock in Local Warehouse, 1-3 days
Origin: China
Shipping: DHL, FedEx, TNT, EMS, By Sea, By Air
Can't sell to individuals
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Product Introduction
We supply Methylcobalamin powder
Our company offers high- quality Methylcobalamin powder for your salutary supplement conditions. Our product is precisely manufactured under strict quality control measures to ensure the chastity and energy of the product. With our Mecobalamin, you can easily add this essential vitamin to your quotidian routine and enjoy the multiple health benefits it provides. Trust our reliable and effective service to supply you with top- quality Mecobalamin.
What's Methylcobalamin?
Methylcobalamin is one form of Vitamin B12. It's a water-answerable vitamin that can be attained from beast- rested foods analogous as meat, fish, and dairy, but it can also be taken as a salutary supplement. This penalty, crystalline cream is easy to mix with liquids or include in smoothies and other fashions. It's also available in tablet and capsule form. it is vital for the conservation of healthy caprice- whams cells, and it supports multitudinous metabolic functions throughout the body. By supplementing with it, you can help cover your brain and nervous system from damage and meliorate your overall health and well- being. It provides safe and effective support for issues analogous as habitual fatigue pattern, anemia, and cognitive decline. By boosting Vitamin B12 situations, it can also help meliorate mood and energy situations, making it an ideal choice for those who lead busy, active lives. The cream is easy to transport and use, making it an ideal supplement for people who travel constantly or have difficulty swallowing capsules. It's important to follow the recommended capsule guidelines on the marker to avoid the trouble of bane. In conclusion, it is a safe and effective form of Vitamin B12 that supports multitudinous important fleshly functions. With its high bioavailability and easy use, it's an excellent choice for those looking to meliorate their internal and physical health. By including Mecobalamin in your quotidian routine, you can witness the benefits of better energy, bettered mood, and enhanced cognitive function.
Basic Information
Product Name: Methylcobalamin; Mecobalamin;Vitamin B12
CAS:13422-55-4
MF:C63H90CoN13O14P
MW:1343.4
EINECS:236-535-3
MDL No.:MFCD00082483
Structural formula:
Purity: 99%+
Origin: China
Application: Raw materials of nutritional supplements
Delivery Time: in stock
Technical Specification
Test Items |
Specifications |
Test Results |
Test Methods |
Characteristics |
Dark red crystal or crystalline powder |
Dark red crystalline |
Visual |
Identification A
|
A361nm/A278nm:1.70-1.90 |
1.88 Complies
|
UV
|
Loss on drying |
≤12.0% |
2.3% |
USP<731> |
Assay on dried basis |
96.0%-102.0% |
99.2% |
UV |
Total impurities |
≤3.0% |
1.56% |
HPLC |
7β、8β-lactocyanocobalamin |
≤1.0% |
Not detected |
|
50-carboxycyanocobalamin |
≤0.5% |
0.07% |
|
34-methylcyanocobalamin |
≤2.0% |
Not detected |
|
32-carboxycyanocobalamin |
≤1.0% |
0.78% |
|
8-Epi-cyanocobalamin |
≤1.0% |
0.06% |
|
Any other unidentified impurity |
≤0.5% |
0.31% |
|
Total aerobic bacteria count |
≤1000cfu/g |
30cfu/g |
USP<2021> |
Molds、Yeasts |
≤100cfu/g |
Not detected |
USP<2021> |
E.coli |
Negative |
Not detected |
USP<2022> |
Residual solvents |
Acetone≤0.5% |
0.0078% |
In house |
Conclusion |
This product complied with the specification of USP and in-house standard. |
Package: 1kg; 25kg
Storage conditions: keep tightly closed, store in a cool dry place.
What is the application of Methylcobalamin?
Methylcobalamin powder is a man-made form of vitamin B12, which is an essential nutrient that plays a vital role in many bodily functions. It is a potent and bioavailable form of vitamin B12 and is used to treat a wide range of health conditions. it is an active form of vitamin B12 that is readily absorbed and utilized by the body, making it an ideal supplement for those who have a deficiency in vitamin B12.
One of the primary applications is in the treatment of pernicious anemia, a condition where the body is unable to absorb enough B12 from food sources. The supplement is also used to treat other types of anemia, including megaloblastic anemia, which can occur due to a lack of vitamin B12.
it has also shown effectiveness in supporting nerve health and function. Many studies have shown that it can improve nerve conduction, reduce numbness, tingling, and pain associated with neuropathy, and even help improve cognitive function. For this reason, it has been used to treat conditions such as diabetic neuropathy, multiple sclerosis, and dementia.
In addition, it has been shown to provide a range of other health benefits. It supports immune function, helps lower homocysteine levels, which can contribute to heart disease, and even helps improve mood and energy levels.
Methylcobalamin supplementation is primarily available in the form of capsules, tablets, and injections. Please consult your doctor before taking it, as an overdose can lead to adverse effects.
Overall, it is a highly potent form of vitamin B12 used to treat a variety of health conditions, primarily anemia, nerve-related disorders, and cognitive decline. It offers a range of benefits to make you healthier and happier, and it is well-tolerated and easy to absorb by the body.
Physiological function
Mecobalamin is a therapeutic drug for peripheral nerve disorders. Compared with other vitamin B12 preparations, it has good transferability to nerve tissue. Through methyl conversion reactions, it can promote nucleic acid protein lipid metabolism and repair damaged nerve tissue. It plays a coenzyme role in the synthesis of methionine from homocysteine, particularly in the synthesis of thymidine from deoxyuridine nucleoside, promoting the synthesis of DNA and RNA. In addition, in the experiment of glial cells, this drug enhances the activity of methionine synthase and promotes the synthesis of myelin chemobook sheath lipid phospholipids. Improving metabolic disorders in nerve tissue can promote the synthesis of axons and their proteins, making the delivery speed of skeletal proteins close to normal and maintaining axonal function. its injection also has the ability to inhibit abnormal excitation conduction in nerve tissue, promote the maturation and division of erythrocytes, and improve anemia. it can quickly restore the reduced red blood cell count, hemoglobin, and hematocrit values in rats due to B12 deficiency. Applied to megaloblastic anemia and peripheral nerve disorders caused by vitamin B12 deficiency.
Pharmacological action
Methylcobalamin is a derivative of vitamin B12, named after its chemical structure. It should be called "methylvitamin B12". Its methylated functional group can participate in the methylation transfer activity in the body's biochemical processes, promote the metabolism of nucleic acid, protein, and fat in nerve tissue, stimulate the synthesis of phospholipids in Schwann cells, repair damaged myelin sheaths, and improve nerve conduction speed; It can directly enter nerve cells and stimulate axonal regeneration in damaged areas; Stimulate protein synthesis in nerve cells, enhance axonal synthesis metabolism, and prevent axonal degeneration; Participate in nucleic acid synthesis and promote hematopoietic function. Clinically, it is often used for the treatment of diabetes neuropathy. Long term use of it also has a certain effect on the macrovascular complications of diabetes. Mecobalamin is mainly used for peripheral nerve diseases caused by diabetes and megaloblastic anemia caused by vitamin B12 deficiency. It is widely used clinically with few side effects.
Preparation
The existing synthesis methods for it all involve two steps: cyancobalamin reduction and methylation. The actual operation is a one pot reaction. Common synthesis methods mainly include: using cyancobalamin as raw material, reducing with sodium borohydride, and methylating with iodomethane to prepare it; A method for preparing it using cyancobalamin as raw material, reduced by sodium borohydride, and methylated with dimethyl sulfate; A method for preparing methylcobalamin using cyancobalamin as raw material, reduced by sodium borohydride, and methylated with methyl p-toluenesulfonate; In the presence of cobalt or iron salts, sodium borohydride is used to reduce cyancobalamin, and then trimethyl sulfoxide iodide or trimethyl sulfoxide bromide is used for methylation to prepare it; A method for preparing cobalt cyanide by reducing cobalt cyanide with sodium borohydride and then methylating with dimethyl carbonate.
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