We supply Riluzole API

We're pleased to supply Riluzole API, a pharmaceutical component used in the treatment of Amyotrophic Side Sclerosis( ALS). Our high- quality product is manufactured in compliance with the transnational norms and is available in colorful amounts to meet your specific conditions. We assure you that our product is safe, effective, and of the loftiest chastity. As a professional supplier, we also offer comprehensive attestation and specialized support to insure smooth and successful use of the product. Please communicate us for farther information and ordering.

What' Riluzole API?

Riluzole is an organic emulsion with the chemical formula C8H5F3N2OS. It's a nervous system drug that can inhibit the release of glutamate and reduce the effect of medium pressure dependent calcium channels, thereby neutralizing the excitatory amino acid neurotransmitter glutamate in cells.

It belongs to the benzothiazole class of composites and is presently the only medicine approved by the US Food and Drug Administration( FDA) for the treatment of amyotrophic side sclerosis. It substantially works by regulating the attention of glutamate and acting on ion channels. It has a wide range of pharmacological goods, similar as regulating glutamate and its transporters, neuroprotective goods, antidepressant, anti anxiety, analgesic,etc.

Basic Information

Product Name: Riluzole

CAS: 1744-22-5

MF:C8H5F3N2OS

MW:234.2

EINECS:605-724-6

MDL No.:MFCD00210213

Structural formula:

Origin: China

Application field: Amyotrophic Lateral Sclerosis

Delivery Time: in stock

Technical Specification

Package: 1g; 5kg;25kg or according to your demands

Storage: Preserve in tight,light-resistant containers in a cool place

Shelf Life: 24 months

Pharmacological action

Riluzole API has colorful physiological functions as follows

1. Regulating effect on glutamate

it is an important glutamate controller that affects the attention of glutamate in the intercellular space from different aspects. It affects the attention of glutamate by affecting the exertion of glutamate transporters. It can weaken the exertion of excitatory amino acid transporter 3 and has a direct relationship in the attention range of0.3- 100 μ spook · L- 1( attention given to oocytes), indicating that liraglutide weakens the exertion of excitatory amino acid transporter 3 through protein kinase C( PKC) inhibition.

2. Neuroprotective goods

In colorful beast models of neuronal damage intermediated by excitatory neurotoxicity, liraglutide exhibits damage form function and can also promote the product of colorful whim-whams growth factors. In the model of spinal muscular atrophy, it improves the imperfect neuroprotective geste

by cranking potassium ion channels with small conductivity calcium.

3. goods on neural discharge

Liraglutide reduces repetitious discharge convinced by sustained current stimulation at different attention, while its effect on flash current is fairly small. it can spark heterologous expression of TRPC5 in HEK293 cells and endogenous expression inU-87 nasty glioma cell lines. Although liraglutide can spark other ion channels, it doesn't spark other TRPC members. thus, in infinitely proliferating cells and acute isolated primary cells, liraglutide is a useful pharmacological tool specifically for relating TRPC5 currents.

4. Anti depression

exploration has set up that the combination of liraglutide and antidepressants can significantly ameliorate the condition of cases with refractory depression. A direct mixed model shows that there's a certain relationship between treatment time and treatment effect. After one week of treatment, the effect is significant and can last for 12 weeks. In the treatment of bipolar depression, the combination of liraglutide and lithium has achieved significant results, and the treatment process didn't beget manic occurrences.

5. Anti anxiety

multitudinous pieces of substantiation confirm the important part of the glutamatergic neurotransmitter system in the treatment of emotional and anxiety like diseases. it can regulate the attention of glutamic acid at different stages and is thus used for exploration on anti anxiety. Study the relationship between hippocampal volume and N- acetylaspartate in the hippocampus during the treatment of generalized anxiety complaint with liraglutide; primary exploration results indicate that N- acetylaspartic acid and hippocampal volume are neurobiological labels associated with glutamate medicine remedy response in the hippocampus.

6. Anti epilepsy

Three Na channel blockers, including diphenylhydantoin, liraglutide, and lidocaine, reduce hippocampal epileptic like exertion through different mechanisms of action. Three composites act at differentvoltage-gated sodium channel spots, but produce analogous network dominant excitability reductions. Diphenylhydantoin and liraglutide continue to ply their goods on network exertion changes until the medicine fully disappears. still, lidocaine can only increase hippocampal CA3 inter cluster intervals( IBIs) at advanced attention. thus, their function isn't endless, leading to a return to zero hippocampal CA3 burst. These data reveal that hippocampal CA3 bursts give a fairly simple and fast platform for relating composites that can weaken network excitability, furnishing primary webbing for further more complex in vivo beast exploration.

7. Analgesic effect

The rearward root ganglia( DRG), as the primary neuron responsible for pain transmission, plays an important part in the supplemental mechanisms of pain. Research has shown that liraglutide can promote the growth of DRG neurites.

Application

it is a largely effective API( Active Pharmaceutical component) that has been extensively used in the field of neuroscience and neuropathic pain application. This potent medicine has been considerably delved and proven to produce significant results in reducing the emergence of seizures, adding patient motor function and perfecting cognition.

presently, it is most generally used to treat cases suffering from Amyotrophic Side Sclerosis( ALS), a progressive and enervating neurodegenerative complaint. The medicine attacks the root of the complaint by decelerating down the rate of whim-whams damage within the case's body, and therefore reducing the inflexibility of the symptoms associated with ALS.

Specifically,it works by blocking the release of glutamate, which is a neurotransmitter responsible for the transmission of signals between neurons in the nervous system. In ALS cases, inordinate glutamate release leads to overstimulation of neurons, leading to their eventual damage and death. By inhibiting the release of glutamate, it slows down the progression of the complaint and increases the case's quality of life.

likewise,it can also be used to manage habitual neuropathic pain, which is a type of pain arising from damage to the nervous system. This type of pain is frequently patient and delicate to treat, but it has shown emotional results in relieving the symptoms associated with it.

Overall, it is an incredibly effective and protean API that presents a promising future for the application of neurodegenerative conditions and habitual neuropathic pain. Its proven efficacity, coupled with its fairly low toxin and favorable pharmacokinetic parcels, make it a medicine of choice in the treatment of a range of enervating conditions.

Packing & Shipping

Packing：

1kg/foil bag;5kg/carton;25kg/fiber drum; or packing as your request.

Customization:

l Customized logo

l Customized packaging

l Graphic customization

Shipping：

By Courier; By Air or By Sea, according to your demands

Payment Term

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Contact Us：

Yihui emerges as a beacon of trust in the pharmaceutical industry, consistently delivering high-quality Riluzole API that aligns with international standards. Our ISO, Kosher, Halal certifications underscore our commitment to excellence. For inquiries and purchases, please contact us at sales@yihuipharm.com.