Everolimus API
MW:958.22
Package: 1g/bag;10g/bag;100g/bag
Origin: China
Supply Ability: 50kg per month
Sample Available: Yes
Payment: T/T, LC or DA
Certifications: ISO9001, ISO22000, HACCP, HALAL, KOSHER
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Product Introduction
What is Everolimus API?
Everolimus API is an orally administered immunosuppressant that acts on the targeted signaling pathway. It's a white or out-white crystalline powder with good thermal stability. Its chemical formula is C53H83NO14, molecular weight is 958.23 g/ spook, and CAS number is 159351-69-6. The solubility of everolimus increases with adding pH. It's generally synthesized by chemical conflation. First, the precursor emulsion C51H79NO13 is synthesized, and also deprotection and cyclization way are performed to gain the everolimus product. It should be stored in a cool, dry, and light-avoided place. During the storehouse, it should be defended from humidity, high temperature, and vibration.
Discovery history it was first developed by Novartis, a Swiss pharmaceutical company. Experimenters from the company discovered it from the actinomycete Streptomyces hygroscopicus. In 1999, it was approved for marketing by the European Medicines Agency. In 2009, it was approved for marketing by the FDA.
In current operation it has become one of the generally used medicines in clinical practice and has good efficacity in the treatment of colorful conditions.
Unborn outlook With further exploration, scientists have discovered that it also has other pharmacological goods, similar as antioxidant, anti-inflammatory, and anti-fibroticeffects. Therefore, it has broad operation prospects in other fields. In the future, with further disquisition of its medium of action, it may be discovered and applied to the treatment of further conditions. At the same time, its combination with other medicines is also an exploration hotspot, which will give further possibilities for further expanding its operation range.
Basic Information
Product name | Everolimus |
chemical name | (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-[(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-1-methylethyl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0~4,9~]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone |
CAS | 159351-69-6 |
MF | C53H83NO14 |
MW | 958.22 |
EINECS | 621-003-9 |
MDL No. | MFCD00929329 |
Purity | 99% |
Stability | a fairly stable emulsion with good physical and chemical stability under normal storehouse conditions. It's generally stored at room temperature in a dry and well- voiced place, defended from light and humidity. |
solubility | relatively poorly soluble compound in water.It's largely lipophilic, meaning it has a high affinity for lipid-grounded substances similar to fats or canvases, but low solubility in waterless media. The solubility of Everolimus can be told by factors similar to pH, temperature, and the presence of other excipients. |
Application | Medicine grade or used for research. |
Packing | As per your request |
Storage | Room temp. |
Structural formula |
Quality standard
Items | Specifications | Results |
Appearance | White or off-white powder | White powder |
Identification (HPLC) | Conforms to standard | Complies |
Uv max (95% ethanol) | 267,277,288nm (E1% cm:417, 541,416) | 277nm |
Purity (major constituent +isomer HPLC) | 95.0%~102.0% | 98.4% |
Conclusion: it complies with Enterprise standards. |
Stability
The stability and storage conditions of Everolimus are very important. Here is the relevant information:
Under proper storage conditions, it can maintain stability for a relatively long time. It is relatively stable at room temperature but can degrade when exposed to light, heat, and humidity. Therefore, the following aspects should be considered during storage and usage:
Light: it should be stored in light-resistant containers to prevent direct sunlight exposure. Prolonged exposure to light may cause drug degradation.
Temperature It's recommended to store it within the range of 2- 8 degrees Celsius, similar as in a regular refrigerator. Avoid storing it in high-temperature surroundings or exposing it to direct sun. Humidity: it is also sensitive to humidity. It should be stored in a dry environment and kept in sealed containers to prevent moisture ingress.
Storage conditions
To ensure the quality and stability, the following storage conditions can be followed:
Package sealing: Store it in its original packaging and ensure that the bags or bottles are intact and well-sealed. This helps prevent moisture and air from entering.
Keep away from heat sources: Store it in a location far from heat sources, avoiding direct exposure to sunlight or proximity to heating devices.
Store in a dry place: Choose a dry and cool storage area, avoiding humid environments.
Avoid vibration: Try to minimize strong vibrations or mechanical shocks to prevent crystal breakage or particle damage.
The above information is for reference only, and the specific stability and storage conditions may vary depending on different formulations and manufacturers.
Packing & Shipping
Packing: 1kg/foil bag;5kg/carton;25kg/fiber drum; or packing as your request.
Customization: Customized logo; Customized packaging; Graphic customization
Shipping:
Item | Quantity | ETA time | Shipping Method |
By Courier | ≤50kg | 7-15days | Fedex, DHL,UPS,TNT,EMS ect. Fast and convenient |
By Air | 50kg~200kg | 3-5days | Fast and cheap |
By Sea | Large quantity | 20-35days | Cheapest way |
Payment Term
Why Choose Xi'an Yihui?
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Our Advantage
Rich experience: we have 13 Years of professional experience;
Customers all over the world: sell to more than 100 countries;
Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.
Price advance: low MOQ with competitive price;
Quality certification: ISO; Halal; Kosher certified
After-sales service: Professional team 7*24 hours customer service.
In conclusion
In summary, as a professional Everolimus API manufacturer, we have advanced technology, scale advantage, the best quality, rich production experience, and excellent services. These advantages will make our Everolimus powder stand out in the market competition and win more customer trust and support.
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