What is β-Nicotinamide Adenine Dinucleotide?

β-Nicotinamide Adenine Dinucleotide, shortened as NDA, also known as diphosphopyridine nucleotide( DPN), or Co dehydrogenase I or coenzyme I, exists in two forms in mammals oxidized form( NAD) and reduced form( NADH). The oxidized form( NAD) has maximum ultraviolet immersion at 260nm and accepts a hydrogen snippet and an electron from substrates through colorful dehydrogenases to come the reduced form( NADH), which has maximum immersion at 340nm. NDA is used as a coenzyme in redox responses, as a patron for the ADP- ribose portion in ADP- ribosylation response, and as a precursor of cyclic ADP- ribose, a alternate runner patch. it also serves as a substrate for bacterial DNA ligase and a group of enzymes called sirtuins, which use NAD to remove acetyl groups from proteins.

β nicotinamide adenine dinucleotide participates in colorful physiological conditioning similar as cellular metabolism, energy conflation, and DNA form, and plays an important part in vulnerable function. Under normal conditions, the attention of nicotinamide adenine dinucleotide in the body remains stable, maintaining normal cellular functions. The attention of nicotinamide adenine dinucleotide in the body determines the process and extent of cellular aging, and a drop in attention can accelerate cellular aging. Studies have shown that NAD has a defensive effect against renal ischemic injury caused by ischemic surgery, significantly reducing situations of blood urea nitrogen and creatinine in serum, and guarding against renal tubular damage. NAD( nicotinamide adenine dinucleotide) can effectively cover against renal ischemic injury and has important operations in the development of medicines for precluding and treating renal ischemic injury. In addition, nicotinamide adenine dinucleotide has certain operations in the medication ofanti-inflammatory anesthetics. NAD is involved in regulating formalin- and complete Freund's adjuvant- convinced seditious pain through NAD-dependent deacetylases SIRT1 and SIRT2. SIRT1 and SIRT2 contribute to the inhibitory effect of NAD on seditious pain through different mechanisms, therefore plying analgesic goods on seditious pain.

Basic Information

Product Name: β-Nicotinamide Adenine Dinuclotide powder;

NAD + Free Acid;

beta-Nicotinamide adenine dinucleotide hydrate;

Nicotinamide adenine dinucleotide free acid

CAS:53-84-9

MF: C21H27N7O14P2

MW:663.43

EINECS:200-184-4

Purity:99%

Stability: Stable for 2 years

Application:food grade or used for research.

Packing:As per your request

Structural formula:

Quality standard

Function and application

A.Nicotinamide Adenine dinucleotide powder acts as a cofactor for proton( specifically hydrogen ion) transfer and is involved in numerous cellular metabolic responses. NADH or further directly, NADH H, is its reduced form. It can be reduced and carry up to two protons( written as NADH H). NAD is a coenzyme for dehydrogenases similar as alcohol dehydrogenase( ADH), used in the oxidation of ethanol. It plays an necessary part in glycolysis, gluconeogenesis, the citric acid cycle, and the respiratory chain. The interceders in these responses transfer hydrogen to NAD, converting it into NADH H. NADH H also acts as a carrier of protons and synthesizes ATP through chemiosmotic coupling in the respiratory chain. In terms of immersion, NADH H has immersion peaks at 260nm and 340nm, while NAD only has one immersion peak at 260nm. This is an important property that distinguishes the two. It also serves as the physical base for measuring metabolic rates in numerous metabolic trials. The molar immersion measure of NAD at 260nm is1.78104 L/( molcm), while that of NADH at 340nm is6.210 ³ L/( molcm).

B. NAD+ powder is a necessary coenzyme in organisms and is used in biochemical research, clinical diagnosis, clinical drugs, and drug research.

C. it is a type of coenzyme drug. It is mainly used in adjuvant therapy for coronary heart disease and can improve symptoms such as chest tightness and angina. Adverse reactions may include dry mouth, dizziness, and nausea.

4. It participates in energy metabolism and substance metabolism in the body, which is beneficial for cell repair and renewal. It is used in the treatment of coronary heart disease, myocarditis, leukopenia, and other conditions.

Stability and storage

β-Nicotinamide Adenine Dinucleotide can be preserved with good stability under proper conditions. Here are the general storage conditions and precautions:

a. Storage temperature: Store NAD at -20°C to -80°C in a frozen environment to extend its lifespan. At these temperatures, NAD degrades at a slower rate, maintaining higher activity and stability.

b. Avoid light: it is vulnerable to degradation by light, especially under UV exposure. Therefore, during storage, avoid direct sunlight or strong light sources and use dark-colored glass vials or light-blocking bags for packaging.

c. Dry environment: it is susceptible to moisture-induced decomposition. Ensure that both the container and storage environment of NAD are dry to prevent moisture ingress.

d. Avoid repeated freeze-thaw cycles: Frequent freeze-thaw cycles can negatively impact the stability of NAD powder. Therefore, it is recommended to aliquot NDA into smaller portions according to experimental needs, avoiding multiple freeze-thaw cycles.

In summary, to maintain the stability of nicotinamide adenine dinucleotide, it is advisable to store it in frozen, light-protected, and dry conditions, while avoiding repeated freeze-thaw cycles. This approach maximizes its activity and reliability.

Packing & Shipping

Packing：1kg/foil bag;5kg/carton;25kg/fiber drum;or packing as your request.

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In conclusion

In summary, as a professional β-Nicotinamide Adenine Dinucleotide manufacturer, we have advanced technology, scale advantage, the best quality, rich production experience, and excellent services. These advantages will make our NAD+ stand out in the market competition and win more customer trust and support. if you need β-Nicotinamide Adenine Dinucleotide, pls feel free to contact us any time. we will reply you asap.

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