We supply Eplerenone API

Our company is pleased to offer Eplerenone API, a high- quality active pharmaceutical component that's extensively used in the pharmaceutical assiduity. it is a picky aldosterone receptor antagonist and is used to treat high blood pressure and heart failure. Our Eplerenone is of the loftiest chastity and is manufactured in compliance with cGMP guidelines. We can offer competitive pricing and timely delivery to meet your requirements. Please feel free to communicate us for further information or to request a quotation.

What's Eplerenone ?

Eplerenone is a new picky aldosterone receptor antagonist approved by the National Food and Drug Administration for clinical use in 2002. The pure product is a white or nearly white demitasse, with a stronger negative effect on aldosterone than spironolactone. It has extremely low affinity for androgen and progesterone receptors, minimum adverse responses, and definite remedial goods on hypertension, heart failure, and myocardial infarction. It has smaller adverse responses and good forbearance, making it a good volition to spironolactone. For severe hypertension that can not be controlled by the combination of multiple antihypertensive medicines, the addition can significantly reduce blood pressure, especially the drop in systolic blood pressure. Combined treatment with angiotensin converting enzyme impediments( ACEI) and beta blockers can ameliorate the quality of life and reduce mortality in cases with severe heart failure and myocardial infarction.

Basic Information

Product Name: Eplerenone

CAS: 107724-20-9

MF:C24H30O6

MW:414.49

EINECS:600-850-8

MDL No.:MFCD05662207

Structural formula:

Origin: China

Application: Antihypertension

Delivery Time: in stock

Technical Specification

Package: 100g;500g;1kg; 5kg

Storage: Preserve in tight,light-resistant containers in a cool place

Shelf Life 24 months

Pharmacological action

Eplerenone API widely acts on aldosterone receptors and has a high selectivity towards mineralocorticoid receptors, but has a fairly small affinity for androgens and progesterone receptors. Its affinity for mineralocorticoids is 15- 20 times that of spironolactone, while its affinity for androgens and progesterone receptors is 500 times lower than spironolactone, performing in smaller circumstance of coitus hormone related adverse responses. it can reduce hypertension, as aldosterone may play an important part in the pathophysiological process of rotundity convinced hypertension. thus, it also has a good antihypertensive effect on diet convinced rotundity related hypertension; In addition, it can significantly reduce the ultrafiltration effect of the glomerulus, so it can reduce the proteinuria of hypertensive cases. For hypertensive cases with diabetes, this renal protection effect is more egregious.

Function

Eplerenone is a drug that belongs to a class of medicines known as mineralocorticoid receptor antagonists. It's primarily used to treat conditions related to the cardiovascular system, particularly in managing high blood pressure and heart failure. Its main function is to block the goods of a hormone called aldosterone, which plays a significant part in regulating swab and water balance in the body. Then are its crucial functions:

• Treatment of Hypertension:  It is used to manage essential hypertension( high blood pressure) in grown-ups. By blocking the goods of aldosterone, it helps to drop sodium retention and reduce blood volume, leading to lowered blood pressure.
• Application of Heart Failure: It is also indicated for the treatment of habitual heart failure following a heart attack. It can help ameliorate survival rates and reduce the threat of hospitalization due to heart failure by blocking the dangerous goods of aldosterone on the heart and blood vessels.
• Reduction of Cardiovascular Risk In cases with heart failure and left ventricular dysfunction: It has been shown to reduce the threat of cardiovascular events, similar as heart attack and stroke, when used in confluence with standard curatives.
• Protection of Organs: It may have defensive goods on organs, particularly the heart and feathers, by reducing the damage caused by inordinate aldosterone exertion. This is especially important in conditions where aldosterone situations are elevated, similar as heart failure and certain types of hypertension.
• Preservation of order Function In specific cases:  It can be used to manage certain forms of order complaint by precluding the dangerous goods of aldosterone on the feathers and helping to save renal function.

It's important to note that eplerenone should be used under the supervision of a healthcare professional, as it may interact with other specifics and can beget side goods in some individualities. also, its use should be guided by specific medical suggestions and individual patient characteristics.

Application

Eplerenone, a drug belonging to the class of medicines known as mineralocorticoid receptor antagonists, has several Applications in clinical drug. Then are some of its crucial Applications

• Hypertension( High Blood Pressure) Application: It is used for the treatment of essential hypertension in grown-ups. It works by blocking the goods of aldosterone, a hormone that regulates blood pressure by promoting sodium and water retention in the body. By inhibiting aldosterone, it helps to lower blood pressure, thereby reducing the threat of complications associated with hypertension similar as heart attack, stroke, and order problems.
• Heart Failure Treatment: it is indicated for the Application of habitual heart failure with reduced ejection bit( a measure of the heart's pumping capability). In cases who have endured a heart attack and have signs of heart failure, it can ameliorate survival rates and reduce the threat of hospitalization due to worsening heart failure symptoms. It achieves this by blocking the dangerous goods of aldosterone on the heart and blood vessels, helping to help farther deterioration of heart function.
• Post-Myocardial Infarction( Heart Attack) Application Following a heart attack:  it may be specified to reduce the threat of cardiovascular events and ameliorate issues. It's particularly salutary in cases who have developed heart failure or left ventricular dysfunction as a result of the heart attack.
• Diabetic Nephropathy( order complaint) : it may be used in the Application of diabetic nephropathy, a type of order complaint that affects some individualities with diabetes. By blocking aldosterone receptors in the feathers, it can help reduce proteinuria( inordinate protein in the urine) and decelerate the progression of order damage in diabetic cases.
• Cardiovascular Risk Reduction: it has been shown to reduce the threat of cardiovascular events similar as heart attack, stroke, and cardiovascular death in cases with heart failure and left ventricular dysfunction. It's frequently specified as an adjunct to standard heart failure curatives, including ACE impediments or angiotensin receptor blockers( ARBs), beta- blockers, and diuretics.

These are some of the primary Applications in clinical practice. It's important for cases to use eplerenone as specified by their healthcare provider and to be apprehensive of implicit side goods and relations with other specifics.

Payment Term

Why Choose Xi'an Yihui?

Customer feedback

Xi'an Yihui certificates

Our advantage

Rich experience: we have 13 Years of professional experience;

Customers all over the world: sell to more than 100 countries;

Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition, and functional food.

Price advance: low MOQ with competitive price;

Quality certification: ISO; Halal; Kosher certified

After-sales service: Professional team 7*24 hours customer service.

Where to buy?

In summary, as a professional Eplerenone API manufacturer, we have advanced technology, scale advantage, the best quality, rich production experience, and excellent services. These advantages will make it stand out in the market competition and win more customer trust and support.

If you want to know more about it or are interested in purchasing it, you can contact us at any time. We will reply to you as soon as possible after we see the message.

our contact information:

E-mail: sales@yihuipharm.com
Tel: 0086-29-89695240
WeChat or WhatsApp: 0086-17792415937